Abstract: In order to better control the damage to environment by gangue, the mineral dissolution-release law of the coal gangue under different temperatures and CO2 partial pressure is researched. Hydro chemical simulation to the mineral dissolution-release law of the coal gangue under different temperatures and CO2 partial pressure is done in light of the software of PHREEQC developed by the United States Geological Survey. The results show that all of the coal gangue minerals solubility increases with temperature, however, with the increase of CO2 partial pressure the coal gangue minerals solubility gradually trend to decrease with the rise of temperature. Except for quartz, the solubility of all minerals in the coal gangue increases with the increase of CO2 partial pressure. The solubility of carbonate(calcite)increases rapidly in a nonlinear way with the increase of CO2 partial pressure, but other salts only increase slowly with CO2 partial pressure. In the coal gangue, the higher the concentration of the CO2 partical pressure in the solution, the higher the output of the gangue chemical components released. The higher the temperature, the higher the output of the chemical components released from the gangue under good air permeability.