Abstract: The article discusses the relationship between soil and desertification through analyzing soil regime during desertification process on the basis of data from Puding station of Guizhou karst center. The results indicate that (1) capillary porosity and natural moisture content of the soil decreases as the rocky desertification intensifying; (2)saturated hydraulic conductivity of the soil increases with soil erosion; (3)bulk density of the soil generally increases with the grade of rock desertification; (4) there is a close relationship between desertification and soil nutrient status, and the higher the grade of rock desertification，the lower the soil organic matter, nitrogen, phosphorus, potassium and other nutrient content.