The groundwater system in karst region is the basic water system in Southwest of China karst mountain. The classification of karst groundwater system is a foundation for estimation and use of water resources there. According to the outcome condition of karst water, 3 620 karst groundwater systems are divided, including 1 179 subterranean streams, 1 152 karst spring systems, 562 concentrated drainage systems and 727 decentralization drainage systems. Being based upon the outcome condition of terrain in karst region, five types are divided: bare karst (2 324), bare-covered karst(108), covered karst(275), bare-buried karst (88). Except decentralization drainage karst water system, there are 26 karst groundwater systems with the catchments bigger than 1 000 km^2 in area. In subterranean stream systems, there are 1 049 systems with the catchments between 10 km^2and 500 km^2 in area that accounts to 88.97% of the total, 711 ones with the catchments smaller than 100 km^2 in area that accounts to 60. 3%0 of the total. In karst spring systems, there are 814 systems with the catchments smaller than 50 km^2 in area that accounts to 70.66% of the total. In concentrated drainage systems, there are 303 systems with the catchments between 100 km^2 and 500 km^2 in area that accounts to 53.91% of the total. The result of runoff statistics shows that 286 groundwater systems is more than 1 000 L/s in runoff that accounts for 11.2% of the total and 630 ones are between 50 L/s and 500 L/s in runoff that accounts for 63.73% of the total.