Cave expedition and histoplasmosis, a kind of cave disease

SUN Chenghang

doi:10.11932/karst2023y016

Volume 42 Issue 3

Jun. 2023

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SUN Chenghang. Cave expedition and histoplasmosis, a kind of cave disease[J]. CARSOLOGICA SINICA, 2023, 42(3): 616-626. doi: 10.11932/karst2023y016

Citation:

SUN Chenghang. Cave expedition and histoplasmosis, a kind of cave disease[J]. CARSOLOGICA SINICA, 2023, 42(3): 616-626. doi: 10.11932/karst2023y016

SUN Chenghang. Cave expedition and histoplasmosis, a kind of cave disease[J]. CARSOLOGICA SINICA, 2023, 42(3): 616-626. doi: 10.11932/karst2023y016

Citation:

SUN Chenghang. Cave expedition and histoplasmosis, a kind of cave disease[J]. CARSOLOGICA SINICA, 2023, 42(3): 616-626. doi: 10.11932/karst2023y016

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Cave expedition and histoplasmosis, a kind of cave disease

doi: 10.11932/karst2023y016

SUN Chenghang

Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China

Received Date: 2022-10-05
Accepted Date: 2022-12-15
Rev Recd Date: 2022-10-19

Available Online: 2023-04-10

Abstract

Abstract

Histoplasmosis is an invasive fungal infection, which might breakout among people who are exposed to the Histoplasma capsulatum, usually, Histoplasma capsulatum var. capsulatum. This disease is an occupational disease of cave explorers, but many cavers or cave managers have never learned, or known very little about it. In order to popularize the disease and its prevention among karst cave geologists, cave explorers and managers, this review introduced histoplasmosis through seven sections following the introduction of histoplasmosis as one of the threats faced by cavers during cave survey in the preface. The first section retrospect research history about the discovery of histoplasmosis and its pathogenic fungus, Histoplasma capsulatum, on the basis of papers published by US scientists, Samuel T. Darling in 1906 and 1908, William DeMonbreun in 1934 and 1939, as well as Chester W. Emmons in 1947 and 1948. The second section introduced definition of cave sickness and investigation on the source of infection in cave. The third section summarized the research evidence how bat spread Histoplasma capsulatum to caver, some important papers published in Science by Martha H. Shacklette in 1962 and Marinkelle C J in 1965 were cited in the section. The fourth and fifth section discussed geographical distribution of histoplasmosis in the world and in China, respectively. Furthermore, in the fifth section, the analysis of histoplasmosis cases in China from three different groups in different period, such as case statistics of 1990-2011 by Pan Bo from Shanghai Changzheng Hospital, case statistics of 2001-2014 by Yu Jie from Huashan Hospital and case statistics of 2001-2019 by LYU Xin from Xiangya Hospital, all data showed Yunnan, Hubei, Hunan, Chongqing, Jiangsu, Guangdong, Sichuan, Zhejiang,Shanghai,Guangxi, most cases came from in China. Meanwhile, in the fifth section, the earliest histoplasmosis cases in China in 1950s were looked back. On the basis of histoplasmosis outbreaks in China and the World, the sixth section summarized the knowledge on how to protect cavers from histoplasmosis infection during cave exploration and provided suggestion about how to prevent histoplasmosis outbreaks for cave managers and local health authorities. In addition, a real story on an outbreak of febrile histoplasmosis among Chinese manganese-mine workers in cooperative Republic of Guyana in 2019 was stated on the basis of two papers published in China CDC Weekly, 2019 and Chinese Journal Infection Chemotherapy, 2020 and one thesis published by Chongqing Medical University in 2021. In the final section, it was emphasized how to prevent to carry unintentionally Histoplasma capsulatum through the caving equipment during international visit for joint expedition.
- histoplasmosis,
- Histoplasma capsulatum,
- cave,
- fungus,
- bat

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References(80)

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Cave expedition and histoplasmosis, a kind of cave disease

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Cave expedition and histoplasmosis, a kind of cave disease

doi: 10.11932/karst2023y016

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通讯作者: 陈斌, bchen63@163.com

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