Abstract: In order to grasp the regime of energy eco-footprint and energy eco-footprint efficiency in Guizhou karst area, the regime features of energy ecological footprint and ecological efficiency are analyzed by means of the quantitative research methods of energy efficiency that based on the eco-footprint model from historical data (1978 - 2011) in Guizhou karst area in the paper. The results show that, during the study period, the energy eco-footprint and the value of energy eco-footprint tends to increase progressively, energy eco-footprint intensity tends to descend. The energy ecological footprint and its value in Guizhou, even through improved to some extent, is still lower than the national averaged level. Through gray correlation analysis on the social economic development and the energy eco-footprint, it is proved that the relationship of economic development and energy consumption is very close, so the problem of high energy consumption and economy is more outstanding in Guizhou karst area.