Abstract: Water inrush is one of the most threatening natural hazard in mining， of which karst water is the most common. The Datengxia Dam has raised the surface water level of the Qianjiang River near the Panlong lead-zinc mine. In addition， with mining further toward the deep subsurface， the value of mine water inrush will be significantly increased. Based on the hydrogeological conditions of the Panlong Lead-zinc mine in Guangxi， a numerical model of the Daling section of this mine was established using the software of Visual ModFlow. The measured values and various calculation methods of mine water inrush were used to verify the numerical model. Through simulation calculation， the influence of water impoundment of the Datengxia Dam on the water inrush of different mining elevations is predicted. The results show that the water inrush of the mine pit will increase obviously after the water impoundment of the Datengxia reservoir. In order to reduce the amount of mine water inrush， it is suggested to build a retaining dam at each of the three backfill ports near the shore of the Qianjiang River， and construct a grouting curtain on the east and west sides of the Daling section of the mine. When the water permeability of the curtain body is 3 Lu， the water stop effect can reach 44.21~53.14%.