Abstract: For strong surface cutting, it is in poor groundwater occurrence and barren enrichment, and the shallow aquifer is almost no water in the west of Guizhou, where it is engineering water shortage. The water supply problem in the west should be solved urgently.The Paleokarst developed in Maokou formation of Permian in Guizhou is proved to be a good space for the deep buried groundwater occurrence and migration, which combines the overlying strata to be a deeply buried ground water system with abundant water in the control with good geology and geography . Based on the exploration experimental data, the development of the paleokarst and reservoir characteristics were studied in Maokou formation of Permian of the basalt and siliceous rocks covered areas in western Guizhou .Through the comprehensive analysis, the results show that top paleokarst commonly develop in Maokou formation, which is generally made of karstic fissure. Besides, karst is most concentrated along the fault zone, where groundwater is most concentrated and permeated. Emei mountain basalt area and Maokou paleokarst belt constitute a good “closed-buried” type of reservoir structure, being the important targets of finding the water source to guarantee drinking water security in western Guizhou.